The Mouse Translational Research Accelerator Platform (MouseTRAP) directly addresses the urgent and critical challenge of improving clinical translation and patient outcomes. MouseTRAP is centred on a touchscreen-based system that we have developed that allows us to assess mice on tests of high-level cognition that are very similar or identical to those used in human patients. The automation and standardization inherent in this approach achieves more accurate, robust, and reproducible phenotyping of mice than conventional approaches. MouseTRAP pairs these tests with cutting-edge technologies to record or manipulate neuronal, glial or neurochemical activity, which makes it possible to match—millisecond by millisecond—what is happening in the brain with human-relevant cognitive performance. This can be done in healthy mice or in our extensive catalogue of next-generation disease models, making MouseTRAP a state-of-the-art platform for assessment of robust, reproducible and human-relevant